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Antibodies
Antibodies


Sjogren syndrome

Definition:

Sjogren syndrome is an autoimmune disorder in which the glands that produce tears and saliva are destroyed. The condition may affect many different parts of the body, including the kidneys and lungs.



Alternative Names:

Xerostomia-Sjogren syndrome; Keratoconjunctivitis sicca-Sjogren's



Causes, incidence, and risk factors:

The cause of Sjogren syndrome is unknown. The syndrome occurs most often in women ages 40 - 50. It is rare in children. Young patients usually have signs of another autoimmune disorder first.

The syndrome may be associated with:

Sjogren syndrome affects about 1 - 4 million people in the United States.



Symptoms:

Dryness of the mouth and eyes are the most common symptoms of this syndrome.

Eye symptoms:

Mouth and throat symptoms:

Other symptoms may include:



Signs and tests:

A physical examination reveals dry eyes and mouth. There may be mouth sores because of the mouth dryness.

Tests:



Treatment:

The goal is to relieve symptoms. Dry eyes may be treated with artificial tears, eye-lubricating ointments, or cyclosoporine liquid. Tiny plugs can be placed in the tear drainage ducts to help the tears stay on the surface of the eye.

Disease modifying drugs (DMARDs) similar to those used for rheumatoid arthritis may improve the symptoms of Sjogren syndrome. These include tumor necrosis factor (TNF) inhibiting drugs.

Sipping water throughout the day and chewing sugarless gum may help relieve mouth dryness. Avoid medicines that can cause mouth dryness such as antihistamines and decongestants. Avoid alcohol.

Talk with your dentist about:

  • Solutions to replace minerals in your teeth
  • Saliva substitutes
  • Drugs that help your salivary glands make more saliva

Frequent brushing and flossing of the teeth, and regular dental visits may prevent severe dental cavities caused by dry mouth.

Arthritis symptoms are commonly treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy.



Support Groups:



Expectations (prognosis):

The disease is usually not life-threatening. The outcome depends on what other diseases you have.

There is an increased risk of lymphoma .



Complications:
  • Kidney failure (rare)
  • Lymphoma
  • Pulmonary infection
  • Vasculitis (rare)


Calling your health care provider:

Call for an appointment with your health care provider if you develop symptoms of Sjogren syndrome.



Prevention:



References:

Kruszka P, O'Brian RJ. Diagnosis and management of Sjogren syndrome. Am Fam Physician. 2009;79:465-470.

Taubert M, Davies MR, Black I. Dry Mouth. BMJ. 2007;334:534.




Review Date: 5/31/2009
Reviewed By: Mark James Borigini, MD, Rheumatologist in the Washington, DC Metro area. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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