Reference Index - Disease & Conditions

Back to Health Library

Male urinary system
Male urinary system


IgA nephropathy

Definition:

Nephropathy refers to damage, disease , or other abnormalities of the kidney. IgA nephropathy is a kidney disorder in which antibodies to a protein called IgA build up in kidney tissue.

It is also called Berger’s disease.



Alternative Names:

Nephropathy - IgA; Berger's disease



Causes, incidence, and risk factors:

IgA is a protein that helps the body fight infections. IgA nephropathy (Berger's disease) occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed.

IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis.

The disorder can appear suddenly (acute ), or progress slowly over many years (chronic glomerulonephritis).

Risk factors include::

  • A personal or family history of IgA nephropathy or Henoch Schonlein purpura , a form of vasculitis that affects many parts of the body
  • Caucasian or Asian ethnicity

IgA nephropathy can occur in persons of all ages, but most often affects males in their teens to late 30s.



Symptoms:

There may be no symptoms for many years.

Symptoms include:

  • Bloody urine that starts during or soon after a respiratory infection
  • Repeated episodes of dark or bloody urine
  • Hand and feet swelling
  • Symptoms of chronic kidney disease


Signs and tests:

IgA nephropathy usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder.

There are no specific changes seen during a physical examination. Occasionally, blood pressure may be high or swelling of the body may be present.

Tests include:



Treatment:

The goal of treatment is to relieve symptoms and prevent or delay chronic renal failure .

Medicines may be given to control high blood pressure and swelling (edema ). Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are used. Controlling blood pressure is the most important measure to delay kidney damage.

Corticosteroids, other immunosuppressive drugs, and fish oil have also been used to treat this disorder.

Salt and fluids may be restricted to control swelling. A low to moderateprotein diet may be recommended in some cases.

Some people will need to take medicines to lower their cholesterol.

Eventually, many patients must be treated for chronic kidney disease.



Support Groups:

For additional information and support, see the IgA Nephropathy Support Network website (www.igansupport.org ).



Expectations (prognosis):

IgA nephropathy progresses slowly. In many cases, it does not progress at all. High blood pressure, large quantities of protein in the urine , and increased BUN or creatinine levels (blood tests that reflect kidney functioning) indicate a higher risk for progression of the disorder.

About 25% of adults with IgA nephropathy develop end-stage kidney failure within about 25 years.



Calling your health care provider:

Call your health care provider if you have bloody urine or if your urine output decreases.



Prevention:



References:

In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 122




Review Date: 8/12/2009
Reviewed By: Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, Affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Greater Baltimore Medical Center | 6701 North Charles Street | Baltimore, MD 21204 | (443) 849-2000 | TTY (800) 735-2258
© 2014  GBMC. This website is for informational purposes only and not intended as medical advice or a substitute for a consultation with a professional healthcare provider.