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Blood clots
Blood clots


Factor XII (Hageman factor) deficiency

Definition:

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.



Causes, incidence, and risk factors:

When you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. (Factor XII is a coagulation factor in this series of reactions.)

Each factor has a reaction that triggers the next reaction. The final product of the coagulation cascade is the blood clot.

A lack of factor XII does not cause the affected person to bleed abnormally, but the blood takes longer than normal to clot in a test tube.

Factor XII deficiency is a rare inherited disorder.



Symptoms:

There are usually no symptoms.



Signs and tests:

Factor XII deficiency is usually found when clotting tests are done for routine screening.

Tests may include:



Treatment:

Treatment is generally unnecessary.



Support Groups:



Expectations (prognosis):

The outcome is expected to be good without treatment.



Complications:

There are usually no complications.



Calling your health care provider:

This condition is usually discovered by the health care provider, when prolonged clotting is noticed in the process of running other laboratory tests.



Prevention:

This is an inherited disorder. There is no known way to prevent it.



References:

Kessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 180.




Review Date: 3/2/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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