|Experimental: Arm I (radiotherapy, chemotherapy, monoclonal antibody)
Patients undergo radiotherapy once daily 5 days a week for 5.5 weeks. Patients also receive paclitaxel IV over 60 minutes and carboplatin IV over 60 minutes on days 1, 8, 15, 22, 29, and 36 and trastuzumab IV over 30-90 minutes on days 1, 8, 15, 22, 29, 36, and 57.
Within 5-6 weeks after completion of radiotherapy, all patients undergo surgery.
Beginning 21-56 days after surgery, all patients receive trastuzumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 13 courses in the absence of disease progression or unacceptable toxicity.
|Radiation: radiation therapy
Undergo radiation therapy
- therapy, radiation
Procedure: therapeutic conventional surgery
- MOAB HER2
Other: laboratory biomarker analysis
Procedure: quality-of-life assessment
Other Name: quality of life assessment