Ultrasound, a non-invasive procedure, may have a role in both preoperative planning of oropharyngeal carcinomas, offering improved imaging of tumors relative to adjacent anatomical structures, and post-operative response to treatment by the patient. This possibility has been identified in several case series. However, a scientific norm, or baseline, for ultrasound imagery of the anatomy of the oropharynx has yet to be established.
Establish a normal anatomical baseline of the oral and base of the tongue, speech and swallow function using ultrasound to assist in treatment planning, response to treatment, that may also serve as a predictive tool for swallowing problems in patient with tongue lesions treated with surgery, chemotherapy and radiation, or any combination of the three treatments.
Patients without head and neck cancer (controls, 70 to be recruited), those with confirmed or suspected oropharyngeal squamous cell cancer (cases, 70 to be recruited) and 30 subject volunteers scheduled for tonsillectomy that presents as nonmalignant. Participants, whose treatment has included surgery, or radiation or chemotherapy or a combination of the three treatments, will be assessed at three different time points, baseline (pre-treatment), three months and six months post-surgery.
Risks and Discomforts
Ultrasound is a noninvasive diagnostic tool that has previously been established as a safe and effective imaging tool and does not present a potential for serious risk to the health, safety, or welfare of a subject beyond that of the standard ultrasound technique and instrumentation.
The participant exposure to radiation will be at the time of initial imaging and it will serve as an complimentary diagnostic tool (ultrasound) at times of reassessment.