Dr. Francomano received her undergraduate degree at Yale University and her medical degree from The Johns Hopkins University School of Medicine. She trained in internal medicine and medical genetics at Johns Hopkins and joined the full-time Hopkins faculty in 1984. Dr. Francomano has held positions as chief of the Medical Genetics Branch at the National Human Genome Research Institute, National Institutes of Health and chief of the Human Genetics and Integrative Medicine Section in the Laboratory of Genetics, National Institute on Aging.
She is board-certified in internal medicine, clinical genetics and clinical molecular genetics. She is a member of the American College of Physicians, the American Society of Human Genetics and the American College of Clinical Research. She is a founding fellow of the American College of Medical Genetics.
In 2008, Dr. Francomano was named "Baltimore's Best Medical Geneticist" by Baltimore Magazine. Her interests include hereditary disorders of connective tissue and skeletal dysplasias.